The impact of maternal and paternal birth weights on infant birth weights: the Japan environment and children’s study

2024 Jan 22.

Tomita H , Iwama N , Hamada H, Kudo R , Tagami K , Kumagai N, Sato N , Izumi S , Sakurai K , Watanabe Z , Ishikuro M , Obara T, Tatsuta N , Hoshiai T , Metoki H , Saito M , Sugawara J , Kuriyama S , Arima T , Yaegashi N ; J Dev Orig Health Dis. 2023 Dec;14(6):699-710. doi: 10.1017/S2040174423000387.

This study aimed to evaluate the association between parental and infant birth weights in Japan. In total, 37,504 pregnant Japanese women and their partners were included in this birth cohort study. A multinomial logistic regression model was used to evaluate the associations of parental birth weights with small-for-gestational-age (SGA) or large-for-gestational-age (LGA) infants. Associations between parental birth weight and low birth weight (LBW) infants or macrosomia were also examined, and linear associations between parental birth weight and SGA or LGA were found. The adjusted odds ratios (aORs) for SGA infants per 500 g decrease in maternal and paternal birth weights were 1.50 (95% confidence interval [CI],1.43-1.58) and 1.31 (95% CI, 1.25-1.38), respectively. The aORs for LGA infants per 500 g increase in maternal and paternal birth weights were 1.53 (95% CI, 1.47-1.60) and 1.41 (95% CI, 1.35-1.47), respectively. The association between parental birth weight and LBW infants or macrosomia was also linear. The aORs for LBW infants per 500 g decrease in maternal and paternal birth weights were 1.47 (95% CI, 1.40-1.55) and 1.25 (95% CI, 1.19-1.31), respectively. The aORs for macrosomia per 500 g increase in maternal and paternal birth weights were 1.59 (95% CI, 1.41-1.79) and 1.40 (95% CI, 1.23-1.60), respectively. Parental birth weight was found to be associated with infant birth weight even after adjusting for various parental factors. Furthermore, maternal birth weight was more strongly associated with infant birth weight than with paternal birth weight.

両親の出生体重と乳児の出生体重の関連を日本人37,504人に多項ロジスティック回帰モデルを用いて評価した。母親および父親の出生時体重が500g減少するごとのSGA児の調整オッズ比（aOR）は、それぞれ1.50および1.31であり、母親および父親の出生時体重が500g増加するごとのLGA児のaORは、それぞれ1.53および1.41であった。親の出生時体重とLBW児または巨大児との関連も線形であった。親の出生時体重は、さまざまな親の因子を調整した後でも乳児の出生時体重と関連することが明らかになった。さらに、母親の出生時体重は父親の出生時体重よりも乳児の出生時体重と強く関連していた。